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3 Benefits and Side Effects of UC2/Non-Denatured Type II Collagen (2 Contraindications To Be Noted) [Updated Feb/2023]

Non-denatured type II collagen (UC2/UC-II) has similar efficacy to glucosaminechondroitin and MSM, and is a health food for joints

In empirical medicine, what are the benefits of undenatured type II collagen (UC-II)? Are there any side effects of undenatured type II collagen (UC-II)? See text analysis for details

What is UC2/UC-II/Undenatured Type II Collagen?

UC2/UC-II, short for Undenatured type 2 collagen, is a new patented ingredient for bone and joint health care, mainly extracted from cartilage in the chicken sternum area, and patented low-temperature manufacturing process in GMP certified facilities to maintain its natural structure and ensure specific levels of UC-II collagen.

The special feature is that the word “Undenatured” means that it has not undergone the common hydrolysis denaturation process, and can retain the original three-dimensional helix three-dimensional structure (triple helix form), which is the most biological.

In animal and human experiments, it has been found that non-denaturing type II collagen can activate a special desensitization process after entering the intestine, also known as oral tolerance.Note 3

This process trains immune cells to recognize the right endogenous chondroprotein molecule in tissues, rather than treating it as a foreign invader, thus preventing a cascade of inflammatory reactions and devastating attacks (the main cause of stiffness and pain in bones and joints) in small amounts.

What are the recommended empirical benefits of non-denatured type 2 collagen?

  1. Good for Osteoarthritis (Osteoarthritis)

Osteoarthritis is a common joint disease, although not fatal, but also the main cause of incapacitation in middle-aged and elderly people

According to clinical and imaging surveys, the prevalence of osteoarthritis has skyrocketed from 30% under 1 years old, 40% under 10 years old, and 60% in 50 years old, which is a disease that is sure to occur the longer you live

A double-blind controlled study (90 days, 52 patients with degenerative arthritis) found that taking non-denatured type II collagen (UC-II) helped reduce osteoarthritis index (WOMAC) by 33% compared to glucosamine + chondroitin by 14%.Note 1

Other indicators such as VAS score and Lequesne’s functional index also decreased, with UC-II falling by 40% and 20%, compared with 15.4% and 6% of glucosamine + chondroitin

According to this study, it has been shown that non-denatured type 2 collagen (UC-2) has more than twice the health and improvement effect of glucosamine and chondroitin on bone and joints. However, due to the small sample size, more experiments are needed for further verification

  1. Good for bone health (animal studies)

Osteoporosis is a metabolic disorder associated with reduced bone stability, most commonly decreased bone content and damage to bone structure, which increases the risk of fractures.

Fractures due to osteoporosis are associated with reduced quality of life, increased morbidity, longer hospital stay, increased economic costs, and mortality.

Dual-energy densitometry scans are by far the most widely used procedure to assess bone strength. In addition, the evaluation of novel biochemical markers of bone metabolism in serum and urine has been recognized as an important indicator of bone health.

An animal study in rodents showed that non-denatured type II collagen (UC2) intervention increased bone mineralization and formation, decreased bone resorption, and thus improved bone density. Note 1

*Conclusion: Non-denatured type II collagen may have positive effects on bone health, but human evidence is lacking and needs to be verified

  1. Improve joint pain caused by exercise

Exercise is good for cardiorespiratory fitness, helps with weight loss and brings a range of health benefits, but it also carries the risk of injury.

Depending on the type of exercise, joint injuries caused by gravity are common, mainly caused by incorrect training methods, overuse, sudden changes in direction and falls from high and low levels.

A double-blind controlled study (120 days, in 55 healthy adults without arthritis symptoms on a daily basis) supplementation with non-denatured type II collagen (UC-II) helped to prolong exercise time (before joint pain was felt) and faster recovery from joint discomfort compared with placebo.Note 2

In addition, compared with the baseline, the knee extension performance of the UC-II group was also significantly better than that of the control group.

This shows that supplementation with non-denatured type 2 collagen can indeed help improve joint comfort, flexibility and mobility.

Are there any side effects of UC2/UC-II/Undenatured Type II Collagen?

Based on current clinical studies, undenatured type II collagen (UC-II) is a health ingredient with high safety at the indicated dose. Despite this, potential side effects may occur, including allergies, nausea, heartburn, diarrhea, constipation, tiredness, skin reactions, and headaches

Safety precautions (2 contraindications to use)

  • Do not use if pregnant women, nursing mothers, and those with poor liver and kidney function (because the relevant safety is still unknown)
  • Do not use if you have been allergic to eggs or related meat foods (may induce allergic reactions)

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