Glucomannan is a perennial plant konjac rich in soluble high viscosity fiber, also known as konjac cellulose, konjac powder, konjac gum, has been consumed by humans for hundreds of years, polymer, calorie-free characteristics, regarded as an ingredient to promote weight loss
In empirical medicine, what are the benefits of ingesting glucomannylene? Are there any side effects of glucomannan? See text analysis for details
What is glucomannan?
Glucomannan is a water-soluble polysaccharide substance (formed from the polymerization of mannose and glucose) extracted from the roots and tubers of konjac and is the most important nutrient in konjac because it is a soluble dietary fiber.
Due to the good biocompatibility and biodegradability of glucomannylene, it has been widely used in food, drug carriers, tissue scaffolds, adsorption materials and other fields.
As a nutritional supplement, it has a variety of biological activities, including cholesterol lowering, anti-diabetic, anti-obesity, laxative, prebiotic, and anti-inflammatory, among others, with multiple potential health benefits.
What are the empirical benefits of glucomannan?
1. Glucomannan helps with weight loss
Obesity is now considered a major epidemic of the 21st century, with the World Health Organization (WHO) defining people with a BMI of 30 or above as obese and a BMI between 25 and 30 as being overweight.
According to statistics, 45% of diabetes, 23% of ischemic heart disease, and 41% of cancers can be attributed to overweight and obesity, making it the fifth largest risk factor for death globally, and at least 2.80 million adults die each year from overweight or obesity-related events.
A systematic review (including six randomised controlled trials) noted that oral glucomannan in adults who are overweight or obese but otherwise healthy may help reduce body weight in the short term, but not body mass index (BMI), while studies in children cannot draw any conclusions due to limited data. Note 1
*Conclusion: For adults who are overweight or obese but otherwise healthy, oral glucomannan may provide positive benefits for weight loss in the short term, but limited by small sample sizes and short durations, more long-term trials are needed to confirm its clinical benefit
2. Glucomannan is beneficial to functional constipation in children
The term functional constipation describes constipation without an organic cause, and the definition of constipation varies, including infrequent bowel movements, difficulty, pain, or incompleteness.
Constipation in children is more common between the ages of 2 and 4, and when toilet training begins, 95% of it is functional constipation and the remaining 5% is of organic etiology, ranging from congenital hirocolon disease, anorectal malformations, neuromuscular diseases, metabolic disorders to endocrine disorders.
A systematic literature review and meta-analysis (3 randomized controlled trials, 122 children with functional constipation) showed that glucomannan increased the frequency of defecation, however, there was no significant difference in stool consistency and treatment success. Note 2
*Conclusion: Glucomannan supplementation may have a positive effect on improving functional constipation in children, but limited by small sample sizes and large biological, methodological, and statistical heterogeneity, more well-designed large trials are needed
3. Glucomannan is beneficial to constipation during pregnancy
It is estimated that about 11% to 38% of pregnant women experience constipation, often described as having infrequent bowel movements or difficulty passing bowel movements.
The occurrence factors are mainly related to hormonal changes and pressure on the intestines due to uterine dilation, resulting in reduced bowel movement.
In addition, reduced maternal physical activity and increased vitamin supplementation (such as iron and calcium) are also factors contributing to constipation, which can lead to complications such as stool accumulation, megacolon, ulcers, general weakness, and hemorrhoids.
A controlled study (1 month, 64 pregnant women with constipation during pregnancy) was divided into two groups, with the intervention group given glucomannan treatment (4 grams of gmono mannylcan powder daily, given twice in the morning and evening) and magnesium hydroxide in the control group. Note 3
The results showed that both groups helped to increase the frequency of bowel movements and improve stool consistency, but the effect of grape mannan was more significant.
*Conclusion: For constipation during pregnancy, the use of glucomannan can bring positive help
4. Glucomannan regulates cholesterol
Hypercholesterolemia is one of the main risk factors for atherosclerotic plaque formation (mainly refers to elevated concentrations of LDL cholesterol).
These plaques increase the likelihood of a variety of negative clinical outcomes, common being coronary artery disease, peripheral artery disease, aneurysm, and stroke.
Several factors can contribute to elevated LDL cholesterol levels, including genetics, diet, stress, sedentary lifestyle, medications, and other conditions such as nephrotic syndrome and hypothyroidism.
A systematic literature review and meta-analysis (12 randomized controlled trials with 370 participants) showed that intake of glucomannan (daily dose between 2 g and 15 g for 3 to 12 weeks) reduced LDL cholesterol and non-HDL cholesterol by 10% and 7%, respectively. Note 4
In addition, 6 of the study data showed no significant effect on apolipoprotein B.
*Conclusion: Oral glucomannan has a positive effect on improving cholesterol, but more long-term large trials are needed to support this
5. Glucomannan is beneficial to functional gastrointestinal diseases
Functional Gastrointestinal Disorder is a common diagnosis of chronic abdominal pain in children and adolescents, with a prevalence of between 10% and 21% in children and adolescents, according to epidemiological data.
The pathogenesis may involve a variety of physiological disorders: hyperkinesia, visceral hypersensitivity, altered mucosal immune function, changes in the intestinal flora, defects in central pain regulation mechanisms, psychosocial and environmental stressors.
A double-blind, placebo-controlled, randomized trial (4 weeks, 89 children with pain-related functional gastrointestinal disease) found that glucomannan intake was not significantly helpful in the main treatment indicators: no pain and treatment success. Note 5
In addition, there were no significant differences in secondary measures such as abdominal cramps, bloating, episodes of nausea or vomiting, or changes in stool firmness.
*Conclusion: For children with pain-related functional gastrointestinal diseases, the use of glucomannan is not helpful for disease improvement, but due to the small sample size and short process, more studies are needed to confirm its clinical benefit
Are there any side effects of glucomannan?
As a food, and when consumed in moderate amounts, glucomannan is generally considered safe and highly tolerated.
However, possible side effects or adverse effects that have been reported include bloating, soft stools, or diarrhoea.
Safety precautions (8 contraindications for use)
1. Consumption of solid tablets containing glucomannan may cause blockage of the esophagus or gastrointestinal tract, in order to reduce the occurrence of such cases, please use with water
2. If the esophagus or intestine structure is abnormal (stricture), please avoid use, which may cause dysphagia, esophageal or gastric obstruction, and even the risk of suffocation
3. Do not use by pregnant and lactating women, as the relevant safety is unknown
4. Because grape glycan has the potential ability to lower blood sugar, it should not be combined with hypoglycemic drugs or insulin, which may cause hypoglycemia, and related drugs should not be named: Glimepiride, glyburide, pioglitazone, rosiglitazone, chlorpropamide, chlorpropamide, Glipizide, tolbutamide
5. Do not combine with other oral drugs, which may affect drug absorption and reduce drug efficacy, in order to prevent such interactions, the interval between the two is at least 3 hours.
6. There has been a rare case of cholestatic hepatitis in a bariatric patient after using glucomannan, and it is unknown whether there is a direct connection. Note 6
7. Some food factory employees experienced asthma, diffuse urticaria, shortness of breath, chest tightness, stridor, hoarseness and other discomfort after inhaling grape manna powder. Note 7
8. Patients with hypothyroidism should refrain from using glucomannan as glucomannan may have the effect of lowering thyroid hormones. Note 8
How to eat glucomannan? What is the dose?
Glucomannan is used in lower doses than other fiber supplements because it absorbs up to 50 times its weight.
If you have not used the product before, it is recommended to try it once a day starting with a small dose
For weight loss, the best time to use is from 15 minutes to 1 hour before meals, about 1 gram each time (and with 250 ml of boiled water), unless taken before meals, it has no effect on weight loss.
*The principle behind it is related to the feeling of satiety and reduced calorie intake after ingestion.
Where can I buy the highest quality Glucomannan that is recommended by most people?
Nature's Way, Glucomannan from Konjac Root, 665 mg, 100 Vegan Capsules
(Direct shipping from the United States / Worldwide delivery)
Nature's Way is a health food manufacturer founded in the United States with a history of more than 50 years, with a very high sales and repurchase rate in major drugstores
Certified by Tru-ID third-party testing to ensure that the ingredients are pure and adulterated