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What is Gepan® instill?

Gepan® instill is a pH-neutral, sterile solution which contains chondroitin sulphate (0.2%), a natural component of the protective layer of the bladder.

Gepan® instill is applied for the treatment of chronic forms of cystitis, e.g. interstitial cystitis, overactive bladder, radiation cystitis and chronically-recurring cystitis. These diseases are often associated with a damage of the glycosaminoglycan-layer of the bladder. The glycosaminoglycan-layer – or GAG-layer is a protective mucous membrane lining the bladder wall. 

GAG Layer Intact  GAG Layer damaged  GAG Layer restored 
Intact GAG-layer


Damaged GAG-layer


Gepan instill restored GAG-layer


Therapy with Gepan® instill can improve symptoms and quality of life of patients by replenishing the glycosaminoglycan-layer – like a kind of liquid band aid on a wound.

What does Gepan® instill do?

Gepan® instill temporarily replaces the deficient GAG layer on the bladder wall. Gepan® instill can provide relief from distressing symptoms such as urgency, frequency and pain and improve quality of life in chronic forms of cystitis.

How is Gepan® instill administered?

Gepan® instill is instilled directly into the previously emptied bladder with the aid of a catheter. You should keep Gepan® instill in the bladder as long as possible, but for at least half an hour.

 How long do I need treatment for?

The frequency of use and duration of treatment with Gepan® instill depend on the intensity of your symptoms. At the start of treatment, 4 to 6 instillations at weekly intervals have proved successful. Depending on your particular needs, your doctor may then adjust your therapy to one instillation per month.

 Does Gepan® instill have any side-effects?

Research has shown that Gepan® instill is well tolerated and causes few, if any adverse reactions. Occasionally, some localised irritation has been experienced as a result of the instillation procedure itself, rather than as a side-effect of Gepan® instill.

 How do I obtain treatment with Gepan® instill?

Gepan® instill requires administration by qualified medical personnel. Please ask your doctor (e.g. urologist or gynaecologist) if Gepan® instill is appropriate for your condition.

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