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5 kinds of effects and side effects of oryzanol (please pay attention to the contraindications for 2 points)

Oryzanol was first extracted from rice bran oil in 1954. In addition to rice, it is found in barley, corn, wheat, oats, asparagus, tomatoes, peas, berries, olives, vegetables, fruits (especially citrus fruits) and several other foods. I can find it in a small amount

The name of Gamma Oryzanol is derived from oryza. It was originally found in rice bran oil. It consists of a hydroxyl group (-nol), hence the name Gamma Oryzanol (γ-oryzanol).

Originally oryzanol was considered to be a single compound, but the molecular structure was later identified as a mixture of phytosterol ferulic acid esters, composed of ferulic acid esters and plant sterols (sterols and triterpene alcohols)

In oryzanol, at least 10 phytosterol ferulates have been found, of which cycloartenyl ferulate, 24-methylenecycloartanyl ferulate, campesteryl ferulate, β-sitosteryl ferulate are the main components, accounting for about 80%

 

What are the empirical effects (benefits) of oryzanol?

  1. Good for blood lipid regulation

Dyslipidemia includes: hypercholesterolemia, hypertriglyceridemia, mixed hyperlipidemia, and low concentrations of serum high-density lipoprotein cholesterol (HDL-c).

As we all know, long-term hyperlipidemia can lead to atherosclerosis, cardiovascular disease, stroke, acute pancreatitis and kidney disease, and also increase the risk of breast cancer and other malignancies

A study (16-week period, 20 patients with chronic schizophrenia with dyslipidemia) pointed out that oral gamma-oryzanol (100 mg three times a day, each time) can reduce total cholesterol and low-density fat Protein cholesterol (low-density lipoprotein cholesterol), and increase high-density lipoprotein cholesterol (High-density lipoprotein cholesterol) levels. Note 1

Another double-blind randomized controlled trial (4 weeks, 59 patients with hyperlipidemia) pointed out that compared with the control group, consumption of rice bran oil rich in gamma-oryzanol significantly reduced low-density lipoprotein cholesterol ( LDL-C) level, in addition, the antioxidant status (measured by oxygen radical absorbance capacity and ferric reducing antioxidant power) has also been significantly improved. Note 2

The underlying mechanism is related to gamma-Oryzanol inhibits HMGCoA reductase and induces the release of cholesterol 7-α-hydroxylase (CYP7A1) (these two are key enzymes involved in liver cholesterol synthesis)

*Conclusion: For hyperlipidemia, the intake of oryzanol may have a positive effect on blood lipid regulation, but it is limited by the small number of samples, and more long-term large-scale trials are still needed for further verification

 

  1. Increase muscle strength

Skeletal muscle is a motor organ and a major contributor to energy expenditure during rest. It is the largest reservoir for blood sugar processing under the stimulation of insulin after a meal.

In addition to its obvious role in exercise and movement, the maintenance of skeletal muscle is vital to metabolic health. Its quality and function below expected standards are related to various negative health outcomes, such as increased risk of cardiovascular disease, cancer, and disability.

A randomized double-blind controlled trial (9 weeks, 30 healthy volunteers), divided into two groups, after training, taking γ-Oryzanol supplement (600 mg) or placebo (equivalent lactose). Note 3

It was found that there was no significant difference in anthropometric and skinfold thickness measurement scores between the supplement group and the placebo group, but taking oryzanol improved the muscle strength measurement scores after resistance training.

*Conclusion: Supplementing oryzanol may have a positive effect on improving muscle strength performance after exercise, but it is still limited by the small sample size, and more research is needed for further verification

 

  1. Beneficial cognitive function (animal research)

Cognitive function (Cognitive Function), including: learning, problem solving, memory and the appropriate use of stored information is the key to health.

Aging has an adverse effect on cognition. Many studies have shown that after the age of 70, approximately 16% of people will have mild cognitive impairment and 14% will develop dementia.

Animal studies point out that Gamma-Oryzanol is a natural compound that can maintain and enhance brain cognitive functions to maintain brain reserves, thereby preventing clinical symptoms or signs of neurodegenerative diseases. Note 4

*Conclusion: Animal studies point out that oral oryzanol has a positive effect on maintaining or improving cognitive function, but further verification by human studies is needed

 

  1. Inhibit tumor growth (animal research)

Cancer is still a major public health problem in the world, and the global cancer burden continues to increase. In the diagnosis of advanced cancer, chemotherapy is still the most effective means to improve the quality of life of patients and prolong survival.

Despite these improvements, current treatment methods have little effect on the 5-year overall survival of patients with advanced disease, and drug resistance is still a major obstacle to successful treatment.

Natural products play an important role as an effective source of anti-tumor drugs. It is estimated that as many as 30% to 40% of anti-cancer drugs used worldwide come from plant sources. The development of medicinal plants continues to bring great hopes for cancer prevention and treatment.

An animal study pointed out that oryzanol can inhibit tumor growth by inducing NK cell activity, activating macrophages, and inhibiting angiogenesis. Note 5

*Conclusion: Animal studies point out that oryzanol may be helpful in inhibiting tumor growth, but it still needs further verification by human studies

 

  1. Good for Type 2 Diabetes (Animal Research)

Type 2 diabetes (type 2 diabetes) is caused by insulin resistance, which is an abnormal response to insulin-mediated cell activity, accompanied by a relative shortage of pancreatic β cells

Insulin is a peptide hormone secreted by pancreatic β cells. It can promote glucose uptake by cells, regulate sugar, lipid, and protein metabolism, promote cell division and growth, and maintain normal blood sugar levels.

Two animal studies pointed out that oryzanol can increase insulin sensitivity, improve islet B cell dysfunction and subsequent apoptosis. Note 6, Note 7

*Conclusion: Animal studies point out that oryzanol may be helpful for blood sugar control, but it still needs further verification by human studies

 

Are there any side effects of oryzanol?

Up to the present limited human studies, for most adults, oryzanol is considered safe when taken orally, and no obvious side effects or adverse reactions have been reported.

Studies on rats have pointed out that oryzanol is a promoter of lung cancer in rats, but its effect is weak and only works at very high dose levels. Note 9

Other animal studies believe that oryzanol is not carcinogenic, even at high doses (2000 mg/kg body weight). Note 10, Note 11

Safety precautions (2 points of use taboo)

  1. Do not use for pregnant and breastfeeding women (because the relevant safety is unknown)
  2. Do not use in patients with abnormal thyroid function, because oryzanol may reduce the level of thyroid-stimulating hormone. Note 8